Proton pump inhibitors for the treatment of eosinophilic oesophagitis

How effective are proton pump inhibitors?

Proton pump inhibitors are drugs that inhibit the production of gastric acid and are approved for the treatment of heartburn and stomach ulcers, but not specifically for the treatment of EoE. Their effect in EoE patients is probably not based on inhibition of acid production in the stomach, but possibly on what is known as an immune-mediated effect in the oesophageal wall. In clinical studies, approximately 30-50 % of EoE patients respond to treatment with high-dose proton pump inhibitors.

Please talk to your doctor for further information.

What are the possible side effects of proton pump inhibitors?

Proton pump inhibitors are considered to be relatively safe. The most common side effects include headache, abdominal pain, constipation, diarrhoea, flatulence, nausea/vomiting and benign fundic gland polyps.